Net Clinical Benefit of Direct Oral Anticoagulants in Patients With Cancer and Venous Thromboembolism: A Systematic Review and Trade-Off Analysis
نویسندگان
چکیده
منابع مشابه
Direct oral anticoagulants and venous thromboembolism.
Venous thromboembolism (VTE), consisting of deep vein thrombosis and pulmonary embolism, is a major clinical concern associated with significant morbidity and mortality. The cornerstone of management of VTE is anticoagulation, and traditional anticoagulants include parenteral heparins and oral vitamin K antagonists. Recently, new oral anticoagulant drugs have been developed and licensed, includ...
متن کاملDirect Oral Anticoagulants for Venous Thromboembolism: A Pharmacological Review.
V thromboembolism (VTE) is an overarching term applied to either deep vein thrombosis (DVT) or pulmonary embolism. VTE is considered to be the third most common cardiovascular disorder after coronary heart disease and stroke.1 An estimated 900 000 cases of VTE occur each year in the United States, and upwards of 60% of cases occur in hospitals or nursing homes.2 Quite often, VTE develops within...
متن کاملProlonged anticoagulation in VTE with direct oral anticoagulants: towards an individual analysis of net clinical benefit?
Venous thromboembolism (VTE) is a common, multifactorial and capricious disease. Its incidence is estimated at between 1 and 1.84 per 1000 person-years, half of cases consisting of isolated distal or proximal deep vein thrombosis (DVT), a quarter of isolated pulmonary embolism (PE) and the rest being PE associated with DVT [1, 2]. The direct severity depends on the mortality risk due to haemody...
متن کاملNew oral anticoagulants in the treatment of acute venous thromboembolism - a systematic review with indirect comparisons.
BACKGROUND For decades, heparins and vitamin K antagonists (VKAs) have been the gold standards in therapy of venous thromboembolism (VTE). The advent of factor IIa and Xa inhibitors provides new therapeutic options. The aim of this analysis is to compare the currently available new oral anticoagulants (NOACs) with VKAs and also indirectly the NOACs with each other, as it is unlikely that a head...
متن کاملDirect oral anticoagulants for acute venous thromboembolism: closing the circle?
I n the past decades, the two-stage treatment of initial paren-teral heparin followed by vitamin K antagonists has been the standard therapy for patients with acute venous thrombo-embolism (VTE). With the advent of direct oral anticoagu-lants (DOACs), previously known as new oral anticoagulants, this era has come to an end. In this issue of Circulation, Schulman et al 1 report on the results of...
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ژورنال
عنوان ژورنال: Frontiers in Cardiovascular Medicine
سال: 2020
ISSN: 2297-055X
DOI: 10.3389/fcvm.2020.586020